Impact of cough across different chronic respiratory diseases: comparison of two cough-specific health-related quality of life questionnaires.

Autors:	Liam Polley, Nurman Yaman, Liam Heaney, Chris Cardwell, Eimear Murtagh, John Ramsey, Joseph Macmahon, Richard W Costello, Lorcan McGarvey
Idioma:	Eng.
Data:	2008-08-06
Revista:	Chest (0012-3692)
Lliurament:	Chest. 2008 Aug;134(2):295-302
Abstract:	BACKGROUND: Cough is a prominent symptom across a range of common chronic respiratory diseases and impacts considerably on patient health status. METHODS: We undertook a cross-sectional comparison of scores from two cough-specific health-related quality of life (HRQoL) questionnaires, the Leicester Cough Questionnaire (LCQ), and the Cough Quality of Life Questionnaire (CQLQ), together with a generic HRQoL measure, the EuroQol. Questionnaires were administered to and spirometry performed on 147 outpatients with chronic cough (n = 83), COPD (n = 18), asthma (n = 20), and bronchiectasis (n = 26). RESULTS: There was no significant difference in the LCQ and CQLQ total scores between groups (p = 0.24 and p = 0.26, respectively). Exploratory analyses of questionnaire subdomains revealed differences in psychosocial issues and functional impairment between the four groups (p = 0.01 and p = 0.05, respectively). CQLQ scores indicated that chronic coughers have more psychosocial issues than patients with bronchiectasis (p = 0.03) but less functional impairment than COPD patients (p = 0.04). There was a significant difference in generic health status across the four disease groups (p = 0.04), with poorest health status in COPD patients. A significant inverse correlation was observed between CQLQ and LCQ in each disease group (chronic cough r = - 0.56, p < 0.001; COPD r = - 0.49, p = 0.04; asthma r = - 0.94, p < 0.001; and bronchiectasis r = - 0.88, p < 0.001). There was no correlation between cough questionnaire scores and FEV(1) in any group, although a significant correlation between EuroQol visual analog scale component and FEV(1) (r = 0.639, p = 0.004) was observed in COPD patients. CONCLUSION: Cough adversely affects health status across a range of common respiratory diseases. The LCQ and CQLQ can each provide important additional information concerning the impact of cough.
Copyright:	Chest Department of Medicine, The Queen's University of Belfast, Northern Ireland.
Full text:	DOI - Chest (DOI) EBSCO - HTML (amb subscripció) HighWire Press - HTML (amb subscripció) MD Consult - HTML (amb subscripció) Ovid Technologies, Inc. - HTML (amb subscripció)
Temes:	Adult, Aged, Asthma, Bronchiectasis, Chronic Disease, Cough, Female, Health Status Indicators, Humans, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive, Quality of Life, Questionnaires, Reproducibility of Results