BACKGROUND:
The Mdm2-SNP309(T/G) polymorphism has been shown to upregulate transcription of Mdm2 and subsequently attenuate the p53 pathway.
Its role in regulating the human response to acute illness has not been reported.
METHODS:
Patients from the surgical intensive care unit were prospectively enrolled. SNP309 genotype was determined, and a genotype-based comparison of clinical outcomes was performed.
RESULTS:
Of the 85 enrolled patients, 41 had wild type (T/T) and 44 had mutant (32 T/G and 12 G/G) genotypes.
The mutant-genotype group tended to have a longer LOS in both the surgical intensive care unit (P = .40) and the hospital (P = .08), but these trends did not reach significance.
No observable genotype-based differences were noted in any other measured parameters.
CONCLUSIONS:
The Mdm2-SNP309(G) allele may be associated with longer LOS. However, it does not appear to influence any other clinical characteristics, nor can it be used to predict clinical outcome.
2008-12-22
Eng.
American Journal of Surgery
Division of Surgical Sciences, Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Am J Surg. 2009 Jan;197(1):43-8
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