To analyse the contribution of socio-demographics, clinical profile and psychotropic treatment on remission in patients with schizophrenia.
Among 933 French outpatients recruited in the European observational Schizophrenia Outpatient Health Outcomes study (SOHO), 563 were followed-up for 3 years, had at most one missing visit, and were included in the analysis.
Symptomatic remission was defined as a score of 3 (mild severity) or less on the Clinical Global Impression-Schizophrenia (CGI) overall, positive, negative and cognitive symptom scales, maintained for at least 6 months and without hospitalization. A logistic regression model was used to analyse the factors associated with time in remission.
60.6% of patients achieved remission during the 3-year follow-up. Patients never treated before inclusion in the study (OR=2.3) and those having paid employment (OR=1.4) were more likely to achieve remission.
Higher baseline clinical severity was associated with a significantly lower likelihood of achieving remission: CGI overall (OR=0.67), CGI positive (OR=0.85) and CGI negative (OR=0.74). Compared with olanzapine, other atypicals (OR=0.71) and conventional antipsychotics (OR=0.69) were associated with a lower probability of achieving remission.
Remission can be achieved in a high proportion of patients.
Factors such as being previously untreated, having paid employment and taking olanzapine are predictors of remission.
European psychiatry : the journal of the Association of European Psychiatrists
National Institute of Health and Medical Research-U669, Maison de Solenn, Cochin Hospital, Paris, France. isabelle.gasquet [at] sap.aphp.fr
Eur Psychiatry. 2008 Oct;23(7):491-6
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