Exhaled nitric oxide measurements: correction equation to compare hand-held device to stationary analyzer.

Abstract

INTRODUCTION:
Exhaled nitric oxide (FE(NO)) is a reliable non-invasive marker of airway inflammation.

In 2003 FE(NO) chemiluminescence analyzer (NIOX; Aerocrine AB, Solna, Sweden) was approved by U.S. Food and Drug Administration for monitoring asthma therapy. Recently, the same company developed a portable device using electrochemical sensors (NIOX-MINO; Aerocrine AB). The aim of our study was to compare NIOX-MINO FE(NO) values to those obtained by NIOX and to calculate a correction equation.

METHODS:
Two adequate measurements obtained by NIOX and NIOX-MINO were recorded in 32 subjects (16 females, mean age 41 years).

RESULTS:
FE(NO) values measured by NIOX-MINO were systematically higher than those obtained by NIOX (47.1ppb, IC 95% 35.2-59.1 and 36.9ppb, IC 95% 25.0-49.0, respectively). There was a significant correlation (r=0.998, p<0.001) between FE(NO) measured by the two analyzers and the following conversion equation was calculated as: FE(NO(NIOX))=-1.656(SE=0.61)+0.808(SE=0.009)x FE(NO(NIOX-MINO))

DISCUSSION:
FE(NO) values measured by the portable nitric oxide analyzer are reliable and strongly correlated with values obtained by the standard stationary device, with a systematic difference observed between the two instruments' values that can be described by the conversion equation we provided.

This equation will help clinicians and researchers to compare data obtainable by the two analyzers.

Full Text

• DOI - Respiratory Medicine (DOI)
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Authors

• Stefano Pizzimenti
• Massimiliano Bugiani
• Pavilio Piccioni
• Enrico Heffler
• Aurelia Carosso
• Giuseppe Guida
• Giovanni Rolla

Publication date

2008-08-04

Journal

Journal topics

• Respiratory Tract Diseases

Language

Eng.

Copyright

Respiratory Medicine

Allergy and Clinical Immunology, University of Torino, Azienda Sanitaria Ospedale Mauriziano "Umberto I", Largo Turati 62, 10128 Torino, Italy.

Release reference

Respir Med. 2008 Sep;102(9):1272-5

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• Books of Respiratory Tract Diseases