OBJECTIVE:
Myocardial ischemic damage is reduced by volatile anesthetics in patients undergoing coronary artery bypass graft surgery.
The authors tested the hypothesis that low-dose sevoflurane could decrease perioperative myocardial damage, as measured by cTnI release, when compared with placebo, in patients undergoing interventional cardiology procedures.
DESIGN:
A single-blind, randomized controlled trial.
SETTING:
A university hospital.
PARTICIPANTS:
Thirty patients undergoing stenting procedures (May 2005) were included in the present study.
INTERVENTIONS:
The authors randomly assigned 16 patients to breathe sevoflurane (expired end-tidal concentration 1%) and 14 patients to breathe a placebo oxygen/air mix before stenting procedures. MEASUREMENTS AND MAIN
RESULTS:
Postprocedural cardiac troponin I release was measured as a marker of myocardial necrosis.
Sixteen patients had detectable cardiac troponin I levels after stenting procedures, with no difference between groups: 10 in the sevoflurane group (16 patients) versus 6 in the placebo group (14 patients) (p = 0.3). No difference in the amount of postprocedural median (interquartile range) cardiac troponin I release was noted between the sevoflurane group, 0.15 (0-4.73) ng/mL, and the placebo group, 0.14 (0-0.87) ng/mL (p = 0.4).
CONCLUSIONS:
Myocardial damage measured by cardiac troponin release was not reduced by the volatile anesthetic sevoflurane during interventional cardiology procedures in this study.
2008-07-29
Eng.
Journal of cardiothoracic and vascular anesthesia
Department of Cardiothoracic Anesthesia and Intensive Care, Università Vita-Salute San Raffaele e Istituto Scientifico San Raffaele, Milan, Italy. landoni.giovanni [at] hsr.it
J Cardiothorac Vasc Anesth. 2008 Aug;22(4):543-7
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