OBJECTIVE:
Preoperative staging of patients diagnosed with prostate cancer is vital in determining the correct treatment including radical prostatectomy.
Serum prostate-specific antigen (PSA), Gleason score in prostate biopsies and predicted clinical T-stage using digital rectal examination and transrectal ultrasound are known predictors of extraprostatic disease after surgery.
This study analysed whether the percentage of positive biopsy cores was a significant preoperative predictor of extraprostatic disease in patients undergoing radical prostatectomy. MATERIAL AND
METHODS:
An analysis was conducted on 390 consecutive patients who underwent radical prostatectomy at Arhus University hospital from 2000 to 2006. Serum PSA, Gleason score, predicted clinical T-stage and percentage of positive biopsy cores were tested in a univariate analysis, and then a multivariate logistical regression model, to determine whether they were predictors of extraprostatic disease.
RESULTS:
The percentage of positive biopsy cores was, together with T-stage and Gleason score, shown to be a significant predictor of extraprostatic disease in both univariate and multivariate analysis with a p-value of 0.05. The calculation yields a model that can predict risk of non-organ-confined disease in a non-screened population.
CONCLUSION:
Being an independent predictor of extraprostatic disease, the percentage of positive biopsy cores can supplement existing preoperative staging variables as found in current staging nomograms.
2009-02-26
Eng.
Scandinavian journal of urology and nephrology
Department of Urology, Aarhus University Hospital, Skejby, Denmark. martinmortensen [at] hotmail.com
Scand J Urol Nephrol. 2009 ;43(2):109-13
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