Cancer stem cells: the other face of Janus.

Authors:	Sahil Mittal, Randy Mifflin, Don W Powell
Language:	Eng.
Date:	2009-08-14
Journal:	The American journal of the medical sciences (0002-9629)
Release:	Am J Med Sci. 2009 Aug;338(2):107-12


Abstract:	Advances in the field of stem cell biology have provided renewed hopes that stem cells can be used to treat a wide range of genetic diseases and traumatic injuries. However, advances in the field of cancer cell biology have led to formulation of the cancer stem cell hypothesis, which posits that cancers arise from mutant stem cells. Further, this hypothesis proposes that these stem cells account for cancer recurrence, metastasis, and resistance to conventional treatments. Thus, although normal stem cells represent potential effective solutions to numerous clinical problems, when mutated, they may also represent the cause of many human malignancies.
Copyright:	The American journal of the medical sciences Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555-0764, USA.
Full text:	DOI - The American journal of the medical sciences (DOI) Lippincott Williams - HTML (needs subscription) Ovid Technologies, Inc. - HTML (needs subscription) Swets Information Services - HTML (needs subscription)
Terms:	Adult Stem Cells, Animals, Embryonic Stem Cells, Humans, Mesenchymal Stem Cells, Neoplastic Stem Cells, Neurons

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