Tricyclic antidepressant toxicity treated with massive sodium bicarbonate.

Authors:	Jessica E Pierog, Kathleen E Kane, Bryan G Kane, J Ward Donovan, Tracey Helmick
Language:	Eng.
Date:	2009-11-25
Journal:	(1532-8171)
Release:	Am J Emerg Med. 2009 Nov;27(9):1168.e3-7
Abstract:	Tricyclic antidepressant (TCA) morbitity is primarily due to cardiac arrhythmias and hypotension, which become more refractory to treatment as acidosis progresses (Ann Emerg Med. 1985;14:1-9; Clin Toxicol. 2007;45:203-233; Flomenbaum N, Goldfrank L, Hoffman R, et al. Goldfrank's toxicologic emergencies. 8th ed. McGraw-Hill Companies, Inc, 2006). Early recognition and aggressive treatment are necessary for patient survival.
Copyright:	Lehigh Valley Hospital, Bethlehem, PA 18107, USA.
Full text:	DOI - (DOI) EBSCO - HTML (needs subscription) Elsevier Science - HTML (needs subscription) MD Consult - HTML (needs subscription) OhioLINK Electronic Journal Center - HTML (needs subscription) Ovid Technologies, Inc. - HTML (needs subscription) Swets Information Services - HTML (needs subscription)
Terms:	Antidepressive Agents, Tricyclic, Arrhythmias, Cardiac, Cyclohexanols, Desipramine, Electrocardiography, Female, Humans, Middle Aged, Overdose, Sodium Bicarbonate