In both models, VX-166 inhibited apoptosis and reduced histological inflammatory infiltrate although there was a more modest impact on other indices of liver injury.
In addition, TPGS/PEG vehicle also exhibited some anti-inflammatory activity, likely through the antioxidant effects of vitamin E and changes in gut flora/mucosal interactions.
These data suggest that caspase inhibition may represent a valid therapeutic approach; however, further studies to assess the long-term value of more selective caspase inhibition are merited.
2010-08-17
Eng.
Journal of Hepatology
Department of Hepatology & Gastroenterology, St Mary's Hospital Campus, Imperial College London, UK. q.anstee [at] imperial.ac.uk
J Hepatol. 2010 Sep;53(3):542-50
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