Vesiculopustular eruption in a neonate with trisomy 21 syndrome as a clue of transient myeloproliferative disorders.

Abstract

We report the case of a vesiculopustular eruption associated with a transient myeloproliferative disorder (TMD) in a neonate with trisomy 21 syndrome.

Examination of a skin biopsy showed a dermal mixed inflammatory infiltrate including atypical megakaryoblasts.

As the white blood cell count spontaneously normalized, the eruption disappeared.

This case report and review of the literature demonstrates that a vesiculopustular eruption could be an important clue to identify TMD in a neonate.

Full Text

Subjects

• Biopsy
• Down Syndrome
• Female
• Humans
• Infant, Newborn
• Leukocyte Count
• Megakaryocyte Progenitor Cells
• Myeloproliferative Disorders
• Skin Diseases, Vesiculobullous

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Authors

• Fiammetta Piersigilli
• Andrea Diociaiuti
• Renata Boldrini
• Cinzia Auriti
• Marco Curci
• Maya El Hachem
• Giulio Seganti

Publication date

2010-07-29

Journal

Journal topics

• Dermatology

Language

Eng.

Copyright

Cutis; cutaneous medicine for the practitioner

Department of Neonatology, Bambino Gesù Children's Hospital, Rome, Italy.

Release reference

Cutis. 2010 Jun;85(6):286-8

Related books

• Books of Biopsy
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• Books of Down Syndrome
• Books of Leukocyte Count
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• Books of Myeloproliferative Disorders
• Books of Skin Diseases, Vesiculobullous