Can 18-FDG-PET during radiotherapy replace post-therapy scanning for detection/demonstration of tumor response in head-and-neck cancer?

Abstract

The high specificity and positive predictive value for the evaluation of tumor response with PET2 and PET3 might avoid unnecessary salvage surgery in patients with a CR. In contrast to PET3, the sensitivity of PET 2 was low, and the difference in OS between the CR and NCR groups was not significantly different. Therefore, the evaluation of the tumor response with FDG-PET at 4 months after RT completion cannot be replaced by FDG-PET during RT at 47 Gy.

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Subjects

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Agents
• Chemoradiotherapy
• Cisplatin
• Female
• Fluorodeoxyglucose F18
• Follow-Up Studies
• Head and Neck Neoplasms
• Humans
• Male
• Middle Aged
• Positron-Emission Tomography
• Radiopharmaceuticals
• Radiotherapy, Intensity-Modulated
• Remission Induction
• Survival Rate
• Time Factors
• Unnecessary Procedures

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Authors

• Gaëtane Ceulemans
• Mia Voordeckers
• Ashraf Farrag
• Douwe Verdries
• Guy Storme
• Hendrik Everaert

Publication date

2011-10-31

Journal

Journal topics

• Radiobiology

Language

Eng.

Copyright

Department of Nuclear Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium. ceulemansgaetane [at] yahoo.com

Release reference

Int J Radiat Oncol Biol Phys. 2011 Nov;81(4):938-42

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