Low-density lipoprotein apheresis reduces platelet factor 4 on the surface of platelets: a possible protective mechanism against heparin-induced thrombocytopenia and thrombosis.

Abstract

We have demonstrated that LDL apheresis via dextran sulfate absorption removes plasma PF4 and reduces the amount of PF4 on the surface of circulating PLTs. Reduced surface PF4 may decrease antibody formation and/or recognition by HITT antibodies.

These data provide a potential explanation for the near lack of HITT in hypercholesterolemic patients undergoing LDL apheresis.

They also suggest the possibility that LDL apheresis using dextran sulfate adsorption may have therapeutic value in the treatment of HITT.

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Subjects

Authors

Publication date

2011-05-06

Journal

Transfusion
Transfusion (1537-2995)

Journal topics

Language

Eng.

Copyright

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Release reference

Transfusion. 2011 May;51(5):1022-9