In summary, the extent of fluid load reduction that can be achieved by HES 130/0.4 is overestimated.
Use of older HES solutions may be associated with serious side effects, and clinicians should be aware that there is no convincing evidence that third-generation HES 130/0.4 is safe in surgical, emergency, or intensive care patients despite publication of numerous clinical studies.
2011-02-25
Eng.
Anesthesia and analgesia
Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller University, Erlanger Allee 101, D-07747 Jena, Germany.
Anesth Analg. 2011 Mar;112(3):635-45
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