Citalopram plus low-dose pipamperone versus citalopram plus placebo in patients with major depressive disorder: an 8-week, double-blind, randomized study on magnitude and timing of clinical response.

Abstract

Although the MADRS score from baseline to 8 weeks did not differ between groups, PipCit provided superior antidepressant effects and fewer discontinuations compared with citalopram and placebo during the first 4 weeks of treatment, especially in the first week.

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Subjects

• Adolescent
• Adult
• Aged
• Butyrophenones
• Citalopram
• Depressive Disorder, Major
• Double-Blind Method
• Drug Therapy, Combination
• Female
• Humans
• Male
• Middle Aged
• Placebos
• Psychiatric Status Rating Scales
• Scotland
• Serotonin Antagonists
• Serotonin Uptake Inhibitors
• Treatment Outcome
• Young Adult

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Authors

• A G Wade
• G M Crawford
• C B Nemeroff
• A F Schatzberg
• T Schlaepfer
• A McConnachie
• L Haazen
• E Buntinx

Publication date

2011-08-26

Journal

Journal topics

• Psychology, Clinical

Language

Eng.

Copyright

CPS Research, Glasgow, Scotland, UK. alangwade [at] fastmail.fm

Release reference

Psychol Med. 2011 Oct;41(10):2089-97

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