Nuclear expression of the ubiquitin ligase seven in absentia homolog (SIAH)-1 induces proliferation and migration of liver cancer cells.

Abstract

Nuclear accumulation of the E3 ubiquitin ligase SIAH-1 supports different pro-tumorigenic cellular processes associated with tumor growth and tumor cell dissemination in human hepatocarcinogenesis.

It promotes HCC cell proliferation by at least partly employing the transcription factor FBP-3. Therefore, interference with SIAH-1 activity represents a promising approach to suppress HCC growth.

Full Text

• DOI - Journal of Hepatology (DOI)
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Subjects

• Apoptosis
• Carcinoma, Hepatocellular
• Cell Line, Tumor
• Cell Movement
• Cell Nucleus
• Cell Proliferation
• Cell Transformation, Neoplastic
• Cytoplasm
• DNA-Binding Proteins
• Down-Regulation
• Gene Expression Regulation, Neoplastic
• Humans
• Kaplan-Meier Estimate
• Liver Neoplasms
• Nuclear Proteins
• RNA, Small Interfering
• Statistics, Nonparametric
• Transcription Factors
• Transfection
• Ubiquitin-Protein Ligases

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Authors

• Antje Brauckhoff
• Mona Malz
• Darjus Tschaharganeh
• Nisar Malek
• Achim Weber
• Marc-Oliver Riener
• Christopher Soll
• Jana Samarin
• Michaela Bissinger
• Jan Schmidt
• Thomas Longerich
• Volker Ehemann
• Peter Schirmacher
• Kai Breuhahn

Publication date

2011-10-19

Journal

Journal topics

• Liver
• Liver Diseases

Language

Eng.

Copyright

Journal of Hepatology

Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

Release reference

J Hepatol. 2011 Nov;55(5):1049-57

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