Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection.

Abstract

Our results demonstrate that HBx is required to initiate and maintain HBV replication and highlight HBx as the key regulator during the natural infection process.

Full Text

• DOI - Journal of Hepatology (DOI)
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Subjects

• DNA, Circular
• DNA, Viral
• Hep G2 Cells
• Hepatitis B
• Hepatitis B Surface Antigens
• Hepatitis B e Antigens
• Hepatitis B virus
• Hepatocytes
• Humans
• Trans-Activators
• Transcription, Genetic
• Transfection
• Virus Replication

Similar articles

• Hepatocystin/80K-H inhibits replication of hepatitis B virus through interaction with HBx protein in hepatoma cell. (2013-05-02)
• Hepatitis B virus X protein modulates remodelling of minichromosomes related to hepatitis B virus replication in HepG2 cells. (2012-10-26)
• Premature cell cycle entry induced by hepatitis B virus regulatory HBx protein during compensatory liver regeneration. (2008-12-16)
• Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death induction. (2012-10-22)
• Granzyme H of cytotoxic lymphocytes is required for clearance of the hepatitis B virus through cleavage of the hepatitis B virus X protein. (2012-01-06)
• Modulation of apoptotic signaling by the hepatitis B virus X protein. (2012-11-08)
• Hepatitis B virus X gene differentially modulates cell cycle progression and apoptotic protein expression in hepatocyte versus hepatoma cell lines. (2012-05-24)
• [Effects of hepatitis B virus X protein on chronic hepatitis B pathophysiology.] (2012-12-11)
• Creation of a Six-fingered Artificial Transcription Factor That Represses the Hepatitis B Virus HBx Gene Integrated into a Human Hepatocellular Carcinoma Cell Line. (2012-10-05)

Authors

• Julie Lucifora
• Silke Arzberger
• David Durantel
• Laura Belloni
• Michel Strubin
• Massimo Levrero
• Fabien Zoulim
• Olivier Hantz
• Ulrike Protzer

Publication date

2011-10-19

Journal

Journal topics

• Liver
• Liver Diseases

Language

Eng.

Copyright

Journal of Hepatology

Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Trogerstrasse, 30, 81675 Munich, Germany.

Release reference

J Hepatol. 2011 Nov;55(5):996-1003

Related books

• Books of DNA, Circular
• Books of DNA, Viral
• Books of Hep G2 Cells
• Books of Hepatitis B
• Books of Hepatitis B Surface Antigens
• Books of Hepatitis B e Antigens
• Books of Hepatitis B virus
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