Metabotropic regulation of RhoA/Rho-associated kinase by L-type Ca2+ channels: new mechanism for depolarization-evoked mammalian arterial contraction.

Abstract

These findings reveal that calcium channel-induced Ca(2+) release has a major role in tonic vascular smooth muscle contractility because it links membrane depolarization and Ca(2+) channel activation with metabotropic Ca(2+) release and sensitization (RhoA/ROCK stimulation).

Full Text

• DOI - Circulation research (DOI)
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Subjects

• Animals
• Basilar Artery
• Calcium
• Calcium Channel Blockers
• Calcium Channels, L-Type
• Coronary Vasospasm
• Electric Stimulation
• Enzyme Inhibitors
• Hypertension
• Indoles
• Mice
• Mice, Knockout
• Muscle Contraction
• Muscle, Smooth, Vascular
• Nifedipine
• Phosphotransferases (Alcohol Group Acceptor)
• Rabbits
• Rats
• Sarcoplasmic Reticulum
• Vasoconstriction
• Vasospasm, Intracranial
• rho GTP-Binding Proteins
• rho-Associated Kinases

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Authors

• Miguel Fernández-Tenorio
• Cristina Porras-González
• Antonio Castellano
• Alberto Del Valle-Rodríguez
• José López-Barneo
• Juan Ureña

Publication date

2011-05-27

Journal

Journal topics

• Cardiovascular System

Language

Eng.

Copyright

Circulation research

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.

Release reference

Circ Res. 2011 May;108(11):1348-57

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