Growth factor delivery through self-assembling peptide scaffolds.

Abstract

Tethering growth factors to (KLDL)(3) results in long-term delivery, but tethering does not necessarily result in the same bioactivity as soluble delivery, indicating presentation of proteins is vital when considering a delivery strategy.

Full Text

• DOI - Clinical orthopaedics and related research (DOI)
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Subjects

• Adsorption
• Animals
• Biotinylation
• Bone Marrow Cells
• Cattle
• Cells, Cultured
• Chondrocytes
• DNA
• Drug Carriers
• Fluorometry
• Glycosaminoglycans
• Hydrogels
• Insulin-Like Growth Factor I
• Kinetics
• Peptides
• Protein Conformation
• Proteoglycans
• Solubility
• Streptavidin
• Stromal Cells
• Tissue Culture Techniques
• Tissue Engineering
• Tissue Scaffolds
• Transforming Growth Factor beta1

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Authors

• Rachel E Miller
• Paul W Kopesky
• Alan J Grodzinsky

Publication date

2011-09-13

Journal

Journal topics

• Orthopedics

Language

Eng.

Copyright

Clinical orthopaedics and related research

Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, NE47-377, Cambridge, MA 02139, USA.

Release reference

Clin Orthop Relat Res. 2011 Oct;469(10):2716-24

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• Books of Adsorption
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