Pax4 protects adult islets from stress-induced apoptosis by suppressing selective nuclear factor-κB target genes while increasing Bcl-2 levels. Furthermore, it promotes dedifferentiation and proliferation of β-cells through MafA repression, with a concomitant increase in Cdk4 and c-myc expression.
Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland.
Diabetes. 2011 Jun;60(6):1705-15
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