Association of cyclophosphamide use with dental developmental defects and salivary gland dysfunction in recipients of childhood antineoplastic therapy.

Abstract

Children and adolescents who received high doses of cyclophosphamide were at increased risk of dental disturbances.

Cyclophosphamide recipients were also at greater risk of exhibiting very low saliva flow.

This study applied the HDI to patients receiving all forms of antineoplastic treatment and highlights the dose-dependent relation between cumulative dose of cyclophosphamide and dental disturbances.

Full Text

• DOI - Cancer (DOI)
• John Wiley & Sons, Inc. - full-text online
• Swets Information Services - full-text online
• OhioLINK Electronic Journal Center - full-text online
• EBSCO - full-text online

Subjects

• Adolescent
• Antineoplastic Agents
• Child
• Child, Preschool
• Cyclophosphamide
• Dental Caries
• Dental Physiological Processes
• Humans
• Male
• Salivary Gland Diseases
• Tooth
• Tooth Abnormalities

Similar articles

• Secondary solid cancers after allogeneic hematopoietic cell transplantation using busulfan-cyclophosphamide conditioning. (2011-01-07)
• Obesity effects on cyclophosphamide-induced DNA damage in hematopoietic cell transplant recipients. (2012-09-05)
• The status of dental and jaw bones in children and adolescents after kidney and liver transplantation. (2012-12-31)
• A myeloablative conditioning regimen for patients with impaired cardiac function undergoing allogeneic stem cell transplantation: reduced cyclophosphamide combined with etoposide and total body irradiation. (2008-08-04)
• Hematopoietic stem cell deficit of transplanted bone marrow previously exposed to cytotoxic agents. (1993-01-29)
• Chemotherapy dose-intensity and survival for childhood medulloblastoma. (2012-09-20)
• Phase I Trial of G3139, a bcl-2 antisense oligonucleotide, combined with doxorubicin and cyclophosphamide in children with relapsed solid tumors: a Children's Oncology Group Study. (2007-04-19)
• Longitudinal assessment of hematopoietic stem cell transplantation and hyposalivation. (2011-09-15)
• In vivo, synergestic inhibition of MAT-LyLu rat prostatic adenocarcinoma growth by polyamine deprivation and low-dose cyclophosphamide. (1996-10-24)

Authors

• Susan Gyea-Su Hsieh
• Sally Hibbert
• Peter Shaw
• Verity Ahern
• Manish Arora

Publication date

2011-04-27

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Cancer

Westmead Centre for Oral Health, Children's Hospital at Westmead, Westmead, Australia. susan.hsieh [at] gmail.com

Release reference

Cancer. 2011 May;117(10):2219-27

Related books

• Books of Antineoplastic Agents
• Books of Cyclophosphamide
• Books of Dental Caries
• Books of Dental Physiological Processes
• Books of Neoplasms
• Books of Salivary Gland Diseases
• Books of Tooth
• Books of Tooth Abnormalities