Common proteomic changes in the hippocampus in schizophrenia and bipolar disorder and particular evidence for involvement of cornu ammonis regions 2 and 3.

Abstract

Overall, similar protein changes were observed in schizophrenia and bipolar disorder and for the first time indicate that the most prominent proteomic changes occur within the hippocampus in cornu ammonis regions 2 and 3. The cytoskeletal protein septin 11 and the cellular trafficking process of clathrin-mediated endocytosis are implicated by our study.

Full Text

• DOI - Archives of general psychiatry (DOI)
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Subjects

• Adult
• Animals
• Antipsychotic Agents
• Bipolar Disorder
• Blotting, Western
• Clathrin
• Electrophoresis, Gel, Two-Dimensional
• Endocytosis
• Enzyme-Linked Immunosorbent Assay
• Female
• Haloperidol
• Hippocampus
• Humans
• Male
• Mice
• Microdissection
• Middle Aged
• Proteomics
• Schizophrenia
• Septins
• Young Adult

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Authors

• Melanie Föcking
• Patrick Dicker
• Jane A English
• K Oliver Schubert
• Michael J Dunn
• David R Cotter

Publication date

2011-05-03

Journal

Journal topics

• Mental Disorders
• Psychiatry

Language

Eng.

Copyright

Archives of general psychiatry

Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.

Release reference

Arch Gen Psychiatry. 2011 May;68(5):477-88

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