Instability of Foxp3 expression limits the ability of induced regulatory T cells to mitigate graft versus host disease.

Abstract

Instability of Foxp3 expression limits the utility of adoptively transferred iTregs as a source of cellular therapy for the abrogation of GVHD. Blockade of IL-6 signaling augments the ability of in vivo iTregs to prevent GVHD but has no effect on in vitro differentiated iTregs.

Full Text

• DOI - Clinical cancer research : an official journal of the American Association for Cancer Research (DOI)
• HighWire Press - full-text online

Subjects

• Animals
• Antibodies, Blocking
• Bone Marrow Transplantation
• Forkhead Transcription Factors
• Gene Expression Regulation
• Graft vs Host Disease
• Immunologic Factors
• Inflammation
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Phenotype
• Receptors, Interleukin-6
• Signal Transduction
• T-Lymphocytes, Regulatory
• Tretinoin

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Authors

• Amy Beres
• Richard Komorowski
• Masahiko Mihara
• William R Drobyski

Publication date

2011-06-17

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Clinical cancer research : an official journal of the American Association for Cancer Research

Bone Marrow Transplant Program and the Departments of Microbiology, Pathology, and Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Release reference

Clin Cancer Res. 2011 Jun;17(12):3969-83

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