Instability of Foxp3 expression limits the utility of adoptively transferred iTregs as a source of cellular therapy for the abrogation of GVHD. Blockade of IL-6 signaling augments the ability of in vivo iTregs to prevent GVHD but has no effect on in vitro differentiated iTregs.
Clinical cancer research : an official journal of the American Association for Cancer Research
Bone Marrow Transplant Program and the Departments of Microbiology, Pathology, and Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Clin Cancer Res. 2011 Jun;17(12):3969-83
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