Combined effects of ascorbic acid and phosphate on rat VSMC osteoblastic differentiation.

Abstract

We demonstrated that AA combined with Pi increases Ca deposition in rat VSMCs. The role of AA as cofactor in osteoblastic differentiation was demonstrated by phenotypic changes in VSMCs and enhanced bone mineralization key gene expression.

These in vitro preliminary data suggest a potential role for AA combined with Pi in worsening VC.

Full Text

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Subjects

• Actins
• Animals
• Antioxidants
• Ascorbic Acid
• Blotting, Western
• Cell Differentiation
• Cells, Cultured
• Core Binding Factor Alpha 1 Subunit
• Male
• Muscle, Smooth, Vascular
• Osteoblasts
• Phosphates
• RNA, Messenger
• Rats
• Real-Time Polymerase Chain Reaction
• Vascular Calcification

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Authors

• Paola Ciceri
• Elisa Volpi
• Irene Brenna
• Lorenzo Arnaboldi
• Luca Neri
• Diego Brancaccio
• Mario Cozzolino

Publication date

2012-01-30

Journal

Journal topics

• Kidney Transplantation
• Nephrology
• Renal Dialysis

Language

Eng.

Copyright

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Renal Division and Laboratory of Experimental Nephrology, Dipartimento di Medicina e Chirurgia, Facoltà di Medicina e Chirurgia, Università di Milano, Milan, Italy.

Release reference

Nephrol Dial Transplant. 2012 Jan;27(1):122-7

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