Inhibitory effect of caffeine on pacemaker activity in the oviduct is mediated by cAMP-regulated conductances.

Abstract

These results suggest that caffeine activates K(ATP) channels in oviduct myosalpinx.

Since caffeine abolishes slow waves and associated contractions of the myosalpinx, it would have a negative effect on egg transport through the oviduct and may contribute to the documented delayed conception in women consuming caffeinated beverages.

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Subjects

• 1-Methyl-3-isobutylxanthine
• ATP-Binding Cassette Transporters
• Adenylate Cyclase
• Animals
• Biological Clocks
• Caffeine
• Cyclic AMP
• Drug Interactions
• Female
• Forskolin
• Glyburide
• KATP Channels
• Membrane Potentials
• Mice
• Mice, Inbred BALB C
• Muscle Contraction
• Muscle, Smooth
• Oviducts
• Phosphodiesterase Inhibitors
• Pinacidil
• Potassium Channels, Inwardly Rectifying
• Receptors, Drug

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Authors

• Re Dixon
• Sj Hwang
• Fc Britton
• Km Sanders
• Sm Ward

Publication date

2011-05-27

Journal

Journal topics

• Drug Therapy
• Pharmacology

Language

Eng.

Copyright

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV, USA.

Release reference

Br J Pharmacol. 2011 Jun;163(4):745-54

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