Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death.

Abstract

Circulating IL-17(+) β-cell-specific autoreactive CD4 T-cells are a feature of type 1 diabetes diagnosis.

We disclose a novel pathway to β-cell death involving IL-17 and STAT1 and NF-κB, rendering this cytokine a novel disease biomarker and potential therapeutic target.

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Subjects

• Adolescent
• Adult
• Animals
• Apoptosis
• CD4-Positive T-Lymphocytes
• Cell Line, Tumor
• Cytokines
• Diabetes Mellitus, Type 1
• Female
• Humans
• Insulin-Secreting Cells
• Insulinoma
• Interleukin-17
• Interleukins
• Male
• NF-kappa B
• Nuclear Receptor Subfamily 1, Group F, Member 3
• Pancreatic Neoplasms
• Rats
• Rats, Wistar
• STAT1 Transcription Factor
• Tumor Necrosis Factor-alpha

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Authors

• Sefina Arif
• Fabrice Moore
• Katherine Marks
• Thomas Bouckenooghe
• Colin M Dayan
• Raquel Planas
• Marta Vives-Pi
• Jake Powrie
• Timothy Tree
• Piero Marchetti
• Guo Cai Huang
• Esteban N Gurzov
• Ricardo Pujol-Borrell
• Decio L Eizirik
• Mark Peakman

Publication date

2011-07-26

Journal

Journal topics

• Diabetes Mellitus

Language

Eng.

Copyright

Department of Immunobiology, School of Medicine, King’s College London, London, UK.

Release reference

Diabetes. 2011 Aug;60(8):2112-9

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