We report for the time a patient with recurrence of tubulointerstitial nephritis and uveitis (TINU) following renal transplantation.
Our patient was diagnosed at the age of 8 years and, despite treatment with systemic steroids, developed established renal failure.
At the age of 17 years, he underwent a live-related donor renal transplant.
Immunosuppression included tacrolimus, mycophenolate mofetil and prednisolone.
Having had normal renal function for 3 years after transplantation, he developed uveitis and decline in the graft function. A biopsy of the allograft demonstrated recurrent granulomatous interstitial nephritis.
The recurrence of TINU following transplantation suggests a role for circulating autoantibodies in the disease pathology.
2011-09-19
Eng.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Department of Paediatric Nephrology, Royal Manchester Children’s Hospital, Manchester, UK.
Nephrol Dial Transplant. 2011 Sep;26(9):3060-2
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