Brain lipid-binding protein: a marker of differentiation in neuroblastic tumors.

Abstract

Brain lipid-binding protein is strongly expressed in mature and maturing ganglion cells in NT (GN and GNB), whereas it is absent in poorly differentiated neuroblasts of GNB and NB. Cytoplasmic expression of BLBP in NT increases as the cells undergo neural differentiation and is therefore associated with the extent of tumour differentiation and favorable histology.

Full Text

• DOI - Journal of pediatric surgery (DOI)
• Swets Information Services - full-text online
• OhioLINK Electronic Journal Center - full-text online
• Elsevier Science - full-text online
• EBSCO - full-text online

Subjects

• Biopsy, Needle
• Brain Neoplasms
• Carrier Proteins
• Child
• Child, Preschool
• Diagnosis, Differential
• Female
• Ganglioneuroblastoma
• Ganglioneuroma
• Humans
• Immunohistochemistry
• Male
• Neuroblastoma
• Sensitivity and Specificity
• Tumor Markers, Biological
• Tumor Suppressor Proteins

Similar articles

• Genetic and physical interactions between Gα subunits and components of the Gβγ dimer of heterotrimeric G proteins in Neurospora crassa. (2012-08-17)
• Neurotrophins and neurotrophin receptors in human lung cancer. (2001-11-05)
• Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells. (2008-11-04)
• Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells. (2008-03-18)
• T lymphocytes possess receptors for brain myelin small protein. (1990-04-25)
• Neurotrophin-4 dependency of intraepithelial vagal sensory nerve terminals that selectively contact pulmonary NEBs in mice. (2010-06-16)
• Expression of the parathyroid hormone-related peptide gene in retinoic acid-induced differentiation: involvement of ETS and Sp1. (1997-10-06)
• Kinetic Analysis of Neurotrophin-3-Mediated Differentiation of Embryonic Stem Cells into Neurons. (2008-12-30)
• The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. (2007-10-23)

Authors

• Giuseppe Retrosi
• Neil J Sebire
• Mark Bishay
• Edward M Kiely
• John Anderson
• Paolo De Coppi
• Elisa Resca
• Dyane Rampling
• Nelly Bier
• Kevin Mills
• Simon Eaton
• Agostino Pierro

Publication date

2011-06-20

Journal

Journal topics

• General Surgery
• Pediatrics

Language

Eng.

Copyright

Journal of pediatric surgery

Surgery Unit, University College London Institute of Child Health and Great Ormond Street Hospital for Children, WC1N 1EH London, United Kingdom.

Release reference

J Pediatr Surg. 2011 Jun;46(6):1197-200

Related books

• Books of Biopsy, Needle
• Books of Brain Neoplasms
• Books of Carrier Proteins
• Books of Diagnosis, Differential
• Books of Ganglioneuroblastoma
• Books of Ganglioneuroma
• Books of General Surgery
• Books of Immunohistochemistry
• Books of Neuroblastoma
• Books of Pediatrics
• Books of Sensitivity and Specificity
• Books of Tumor Markers, Biological
• Books of Tumor Suppressor Proteins