The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome.

Abstract

In a phase 2 study, LX1031 was well tolerated, relieving symptoms and increasing stool consistency in patients with nonconstipating IBS. Symptom relief was associated with reduced levels of 5-HIAA in urine samples.

This marker might be used to identify patients with nonconstipating IBS who respond to inhibitors of 5-HT synthesis.

Full Text

• DOI - Gastroenterology (DOI)
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Subjects

• Abdominal Pain
• Adult
• Biological Markers
• Biphenyl Compounds
• Constipation
• Double-Blind Method
• Feces
• Female
• Humans
• Hydroxyindoleacetic Acid
• Irritable Bowel Syndrome
• Male
• Middle Aged
• Pain Measurement
• Phenylalanine
• Serotonin
• Severity of Illness Index
• Tryptophan Hydroxylase

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Authors

• Philip M Brown
• Douglas A Drossman
• Alastair J J Wood
• Gary A Cline
• Kenny S Frazier
• Jessica I Jackson
• Johanna Bronner
• Joel Freiman
• Brian Zambrowicz
• Arthur Sands
• Michael D Gershon

Publication date

2011-08-08

Journal

Journal topics

• Gastroenterology

Language

Eng.

Copyright

Gastroenterology

Lexicon Pharmaceuticals, Inc, The Woodlands, Texas 77381, USA.

Release reference

Gastroenterology. 2011 Aug;141(2):507-16

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