Eradication of chemotherapy-resistant CD44+ human ovarian cancer stem cells in mice by intraperitoneal administration of Clostridium perfringens enterotoxin.

Abstract

CPE may represent an unconventional, potentially highly effective strategy to eradicate chemotherapy-resistant cancer stem cells.

Full Text

• DOI - Cancer (DOI)
• John Wiley & Sons, Inc. - full-text online
• Swets Information Services - full-text online
• OhioLINK Electronic Journal Center - full-text online
• EBSCO - full-text online

Subjects

• Adult
• Aged
• Animals
• Antigens, CD44
• Cell Line, Tumor
• Cercopithecus aethiops
• Claudins
• Clostridium perfringens
• Enterotoxins
• Female
• Flow Cytometry
• Humans
• Injections, Intraperitoneal
• Mice
• Mice, SCID
• Middle Aged
• Neoplasms, Glandular and Epithelial
• Neoplastic Stem Cells
• Ovarian Neoplasms
• Real-Time Polymerase Chain Reaction
• Vero Cells
• Xenograft Model Antitumor Assays

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Authors

• Francesca Casagrande
• Emiliano Cocco
• Stefania Bellone
• Christine E Richter
• Marta Bellone
• Paola Todeschini
• Eric Siegel
• Joyce Varughese
• Dan Arin-Silasi
• Masoud Azodi
• Thomas J Rutherford
• Sergio Pecorelli
• Peter E Schwartz
• Alessandro D Santin

Publication date

2011-12-05

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Cancer

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut 06520-8063, USA. alessandro.santin [at] yale.edu

Release reference

Cancer. 2011 Dec;117(24):5519-28

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