The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Δ32 mutation.

Abstract

Both IL28B rs1297860 and CCR5Δ32 allelic variants are independent genetic determinants of spontaneous HCV clearance.

The variable relative distribution between IL28B rs1297860 and CCR5Δ32 allelic variants in different populations may have masked the role of the CCR5Δ32 mutation in some studies.

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Subjects

• Alleles
• Case-Control Studies
• Cohort Studies
• Disease Outbreaks
• Drug Contamination
• Female
• Gene Frequency
• Genotype
• Germany
• Hepatitis C
• Humans
• Interleukins
• Polymorphism, Single Nucleotide
• Receptors, CCR5
• Sequence Deletion

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Authors

• Jacob Nattermann
• Jörg Timm
• Hans Dieter Nischalke
• Anne Olbrich
• Monika Michalk
• Hans L Tillmann
• Thomas Berg
• Heiner Wedemeyer
• Hannelore Tenckhoff
• Manfred Wiese
• Ulrike Kullig
• Uwe Göbel
• Emanuela Capka
• Ingolf Schiefke
• Wolfgang Güthof
• Kurt Grüngreiff
• Ingrid König

Publication date

2011-11-21

Journal

Journal topics

• Liver
• Liver Diseases

Language

Eng.

Copyright

Journal of Hepatology

Department of Internal Medicine, University of Bonn, Bonn, Germany. jacob.nattermann [at] ukb.uni-bonn.de

Release reference

J Hepatol. 2011 Dec;55(6):1201-6

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