Role of cardiac myofilament proteins titin and collagen in the pathogenesis of diastolic dysfunction in cirrhotic rats.

Abstract

Therefore, diastolic dysfunction exists in cirrhosis with alterations in titin modulation, PKA levels, and collagen configuration contributing to the pathogenesis of this condition.

Full Text

• DOI - Journal of Hepatology (DOI)
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Subjects

• Animals
• Base Sequence
• Cardiomyopathies
• Collagen
• Collagen Type I
• Collagen Type III
• Cyclic AMP-Dependent Protein Kinases
• DNA Primers
• Heart Failure, Diastolic
• Liver Cirrhosis, Experimental
• Male
• Muscle Proteins
• Myocytes, Cardiac
• Myofibrils
• RNA, Messenger
• Rats
• Rats, Inbred BN
• Rats, Sprague-Dawley

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Authors

• Tamara K Glenn
• Hooman Honar
• Hongqun Liu
• Henk E D J ter Keurs
• Samuel S Lee

Publication date

2011-11-21

Journal

Journal topics

• Liver
• Liver Diseases

Language

Eng.

Copyright

Journal of Hepatology

Liver Unit, GI Research Group, Calgary, Canada. tamig81 [at] yahoo.com

Release reference

J Hepatol. 2011 Dec;55(6):1249-55

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