Corticosteroids shift the Toll-like receptor response pattern of primary-isolated murine liver cells from an inflammatory to an anti-inflammatory state.

Abstract

TLR signaling is modulated by corticosteroids in a cell type-specific fashion resulting in down-regulation of TLR expression, suppression of pro-inflammatory and up-regulation of anti-inflammatory cytokines.

This represents an as yet unknown mechanism of action for corticosteroids that may at least in part explain their therapeutic effects in inflammatory liver diseases.

Full Text

• DOI - International immunology (DOI)
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Subjects

• Animals
• Anti-Inflammatory Agents
• Cells, Cultured
• Cytokines
• Dexamethasone
• Gene Expression Regulation
• Immunity, Innate
• Ligands
• Liver
• Lymphocyte Activation
• Mice
• Mice, Inbred C57BL
• NF-kappa B
• Signal Transduction
• Toll-Like Receptors

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Authors

• Ruth Broering
• Mario Montag
• Min Jiang
• Mengji Lu
• Jan-Peter Sowa
• Kathrin Kleinehr
• Guido Gerken
• Joerg F Schlaak

Publication date

2011-08-18

Journal

Journal topics

• Immunity
• Immunity, Cellular

Language

Eng.

Copyright

International immunology

Department of Gastroenterology and Hepatology, University Hospital of Essen, Germany.

Release reference

Int Immunol. 2011 Sep;23(9):537-44

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