IGF-2R was consistently overexpressed on the cell surface across all tested osteosarcoma cell lines. Substantial, although variable, expression of c-Met, HER-2, IGF-1R, VEGFR-3, IR, and PDGFR-β was demonstrated as well, suggesting that these receptors may contribute to osteosarcoma aggressiveness and biological heterogeneity and may serve as potential targets within a subset of tumors.
Associated receptor expression may provide new insight into common regulatory factors or pathways.
Targeting either common factors or targeting multiple specific receptors may have therapeutic relevance.
2012-01-23
Eng.
Cancer
Department of Orthopaedic Surgery, Montefiore Medical Center and The Children's Hospital at Montefiore, Bronx, New York 10467, USA.
Cancer. 2012 Feb;118(3):740-9
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