Identification of spliced variants of the proto-oncogene HDM2 in colorectal cancer.

Abstract

The data from the current study provide the first evidence that hdm2 mRNA is frequently mutated by alternative splicing in colorectal cancer, and may play a role in colorectal tumorigenesis or cancer progression.

Full Text

• DOI - Cancer (DOI)
• John Wiley & Sons, Inc. - full-text online
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Subjects

• Alternative Splicing
• Cell Line, Tumor
• Colorectal Neoplasms
• Female
• Humans
• Male
• Middle Aged
• Mutation
• Neoplasm Staging
• Proto-Oncogene Proteins c-mdm2
• RNA, Messenger
• Survival Rate
• Tumor Suppressor Protein p53

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Authors

• Zhiwei Yu
• Bin Zhang
• Binbin Cui
• Yihui Wang
• Peng Han
• Xishan Wang

Publication date

2012-02-06

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Cancer

Division of Colorectal Surgery, Third Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.

Release reference

Cancer. 2012 Feb;118(4):1110-8

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