Estradiol modulates medial prefrontal cortex and amygdala activity during fear extinction in women and female rats.

Abstract

We provide translational evidence that demonstrates the influence of endogenous and exogenous estradiol on the fear extinction network.

Our data suggest that women's endogenous hormonal status should be considered in future neurobiological research related to anxiety and mood disorders.

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Subjects

• Adolescent
• Adult
• Amygdala
• Animals
• Conditioning, Classical
• Estradiol
• Estrogens
• Extinction, Psychological
• Fear
• Female
• Humans
• Image Processing, Computer-Assisted
• Magnetic Resonance Imaging
• Nitriles
• Oxygen
• Prefrontal Cortex
• Propionates
• Proto-Oncogene Proteins c-fos
• Psychiatric Status Rating Scales
• Psychophysics
• Pyrazoles
• Rats
• Rats, Sprague-Dawley
• Time Factors
• Young Adult

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Authors

• Mohamed A Zeidan
• Sarah A Igoe
• Clas Linnman
• Antonia Vitalo
• John B Levine
• Anne Klibanski
• Jill M Goldstein
• Mohammed R Milad

Publication date

2011-10-24

Journal

Journal topics

• Psychiatry
• Psychopharmacology
• Psychophysiology

Language

Eng.

Copyright

Department of Psychiatry, Massachusetts General Hospital, Boston, USA.

Release reference

Biol Psychiatry. 2011 Nov;70(10):920-7

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