Critical role of chemokine (C-C motif) receptor 2 (CCR2) in the KKAy + Apoe -/- mouse model of the metabolic syndrome.

Abstract

CCR2-driven inflammatory monocyte accumulation in the liver and muscle may be a critical pathogenic factor in the development of the metabolic syndrome.

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Subjects

• Animals
• Apolipoproteins E
• Blood Pressure
• Diabetic Nephropathies
• Dyslipidemias
• Eating
• Flow Cytometry
• Humans
• Immunohistochemistry
• Insulin Resistance
• Interleukin-6
• Metabolic Syndrome X
• Mice
• Mice, Knockout
• Receptors, CCR2
• Tumor Necrosis Factor-alpha

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Authors

• H G Martinez
• M P Quinones
• F Jimenez
• C A Estrada
• K Clark
• G Muscogiuri
• G Sorice
• N Musi
• R L Reddick
• S S Ahuja

Publication date

2011-09-08

Journal

Journal topics

• Diabetes Mellitus

Language

Eng.

Copyright

South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio, TX, USA.

Release reference

Diabetologia. 2011 Oct;54(10):2660-8

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