Alloimmunization to transfused HOD red blood cells is not increased in mice with sickle cell disease.

Abstract

In sum, homozygous β(S) expression and the ensuing disease state are not alone sufficient to enhance RBC alloimmunization to transfused HOD RBCs in two distinct humanized murine models of sickle cell disease under the conditions examined.

These data suggest that other factors may contribute to the high rates of RBC alloimmunization observed in humans with sickle cell disease.

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Subjects

• Anemia, Sickle Cell
• Animals
• Disease Models, Animal
• Erythrocyte Transfusion
• Erythrocytes
• Humans
• Immunization
• Isoantibodies
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Mice, Inbred DBA
• Mice, Transgenic
• Muramidase

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Authors

• Jeanne E Hendrickson
• Eldad A Hod
• Jennifer R Perry
• Samit Ghosh
• Prasanthi Chappa
• Olufolake Adisa
• Leslie S Kean
• Solomon F Ofori-Acquah
• David R Archer
• Steven L Spitalnik
• James C Zimring

Publication date

2012-01-13

Journal

Journal topics

• Blood Transfusion
• Hematology

Language

Eng.

Copyright

Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA. jeanne.hendrickson [at] choa.org

Release reference

Transfusion. 2012 Feb;52(2):231-40

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