New horizons for stem cell therapy in liver disease.

Abstract

There is an increasing range of potential applications of stem cells in liver diseases, with many clinical studies already undertaken.

We identify four of the main areas which we propose stem cell therapy could be a realistic aim for in the future: (1) to improve regeneration and reduce scarring in liver cirrhosis by modulating the liver's own regenerative processes, (2) to down-regulate immune mediated liver damage, (3) supplying hepatocyte-like cells (HLCs) derived from stem cells for use in extracorporeal bio-artificial liver machines, and (4) to use stem cell derived HLCs for cell transplantation to supplement or replace hepatocyte function.

Full Text

• DOI - Journal of Hepatology (DOI)
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Subjects

• Hepatocytes
• Humans
• Liver Cirrhosis
• Liver Diseases
• Liver Regeneration
• Stem Cell Transplantation

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Authors

• Stuart J Forbes
• Philip N Newsome

Publication date

2012-01-18

Journal

Journal topics

• Liver
• Liver Diseases

Language

Eng.

Copyright

Journal of Hepatology

MRC Centre for Regenerative Medicine and MRC, Edinburgh University, UK. stuart.forbes [at] ed.ac.uk

Release reference

J Hepatol. 2012 Feb;56(2):496-9

Related books

• Books of Hepatocytes
• Books of Liver
• Books of Liver Cirrhosis
• Books of Liver Diseases
• Books of Liver Diseases
• Books of Liver Regeneration
• Books of Stem Cell Transplantation