Sevoflurane protects ventricular myocytes from Ca2+ paradox-mediated Ca2+ overload by blocking transient receptor potential canonical channels and by preventing the decrease in sarcoplasmic reticulum Ca2+ levels, which is associated with less activation of transient receptor potential canonical channels.
Department of Anesthesiology, Shiga University of Medical Science, Otsu, Shiga, Japan.
Anesthesiology. 2011 Sep;115(3):509-22
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