Sevoflurane protects ventricular myocytes from Ca2+ paradox-mediated Ca2+ overload by blocking the activation of transient receptor potential canonical channels.

Abstract

Sevoflurane protects ventricular myocytes from Ca2+ paradox-mediated Ca2+ overload by blocking transient receptor potential canonical channels and by preventing the decrease in sarcoplasmic reticulum Ca2+ levels, which is associated with less activation of transient receptor potential canonical channels.

Full Text

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Subjects

• Anesthetics, Inhalation
• Aniline Compounds
• Animals
• Calcium
• Cardiotonic Agents
• Electrophysiological Phenomena
• Enzyme Inhibitors
• Fluorescent Dyes
• Heart Ventricles
• Male
• Methyl Ethers
• Mice
• Mice, Inbred C57BL
• Microscopy, Confocal
• Myocytes, Cardiac
• Patch-Clamp Techniques
• Sarcoplasmic Reticulum
• Thapsigargin
• Transient Receptor Potential Channels
• Xanthenes

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Authors

• Akiko Kojima
• Hirotoshi Kitagawa
• Mariko Omatsu-Kanbe
• Hiroshi Matsuura
• Shuichi Nosaka

Publication date

2011-08-25

Journal

Journal topics

• Anesthesiology

Language

Eng.

Copyright

Anesthesiology

Department of Anesthesiology, Shiga University of Medical Science, Otsu, Shiga, Japan.

Release reference

Anesthesiology. 2011 Sep;115(3):509-22

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