Castration resistant prostate cancer is associated with increased blood vessel stabilization and elevated levels of VEGF and Ang-2.

Abstract

CR prostate cancer is associated with elevated levels of VEGF and Ang-2, indicating that these factors could be used as targets for anti-angiogenic treatment. Still, the observed increase in blood vessel stabilization in CR tumors could influence the outcome of anti-angiogenic treatment. Furthermore, increased VEGF expression after 3 months of ADT justifies the use of VEGF-based anti-angiogenic drugs in combination with ADT for the treatment of advanced prostate cancer.

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Subjects

• Aged
• Aged, 80 and over
• Angiopoietin-2
• Humans
• Male
• Middle Aged
• Neovascularization, Pathologic
• Orchiectomy
• Prostatic Neoplasms
• Vascular Endothelial Growth Factor A

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Authors

• Tajana Tešan Tomić
• Heléne Gustavsson
• Wanzhong Wang
• Karin Jennbacken
• Karin Welén
• Jan-Erik Damber

Publication date

2012-04-24

Journal

Journal topics

• Prostate

Language

Eng.

Copyright

Sahlgrenska Cancer Center, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.

Release reference

Prostate. 2012 May;72(7):705-12

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