Monoamine oxidase A binding in the prefrontal and anterior cingulate cortices during acute withdrawal from heavy cigarette smoking.

Abstract

The increase in prefrontal and anterior cingulate cortex MAO-A binding and associated reduction in plasma harman level represent a novel, additional explanation for depressed mood during withdrawal from heavy cigarette smoking.

This finding resolves a longstanding paradox regarding the association of cigarette smoking with depression and suicide and argues for additional clinical trials on the effects of MAO-A inhibitors on quitting heavy cigarette smoking.

Full Text

• DOI - Archives of general psychiatry (DOI)
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Subjects

• Adult
• Carbon Radioisotopes
• Depression
• Diagnosis, Dual (Psychiatry)
• Female
• Gyrus Cinguli
• Harmine
• Humans
• Male
• Monoamine Oxidase
• Positron-Emission Tomography
• Prefrontal Cortex
• Severity of Illness Index
• Smoking
• Substance Withdrawal Syndrome
• Tobacco Use Disorder

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Authors

• Ingrid Bacher
• Sylvain Houle
• Xin Xu
• Laurie Zawertailo
• Alexandra Soliman
• Alan A Wilson
• Peter Selby
• Tony P George
• Julia Sacher
• Laura Miler
• Stephen J Kish
• Pablo Rusjan
• Jeffrey H Meyer

Publication date

2011-08-03

Journal

Journal topics

• Mental Disorders
• Psychiatry

Language

Eng.

Copyright

Archives of general psychiatry

Vivian M. Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, 250 College St., Toronto, ON, Canada.

Release reference

Arch Gen Psychiatry. 2011 Aug;68(8):817-26

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