Hepatitis C virus non-structural 3/4A protein interferes with intrahepatic interferon-γ production.

Abstract

Our data demonstrate that the NS3/4A protease reduces the intrahepatic production of IFNγ and alters TNFα-mediated effects, thereby impairing the hepatic inflammatory response.

This may contribute to viral persistence.

Full Text

• DOI - (DOI)
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Subjects

• Animals
• Carrier Proteins
• Case-Control Studies
• Female
• Hepacivirus
• Hepatitis C
• Humans
• Interferon-alpha
• Interferon-gamma
• Lipopolysaccharides
• Liver
• Lymphocyte Subsets
• Male
• Mice
• Mice, Transgenic
• Middle Aged
• STAT1 Transcription Factor
• Signal Transduction
• Viral Nonstructural Proteins

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Authors

• Erwin Daniel Brenndörfer
• Anette Brass
• Jonas Söderholm
• Lars Frelin
• Soo Aleman
• Johannes Georg Bode
• Matti Sällberg

Publication date

2012-03-02

Journal

Journal topics

• Gastroenterology

Language

Eng.

Copyright

Division of Clinical Microbiology F68, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden. erwin.brenndorfer [at] ki.se

Release reference

Gut. 2012 Apr;61(4):589-96

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