Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury.

Abstract

These results demonstrate the successful pharmacological inhibition of hepatic monocyte/macrophage infiltration by blocking MCP-1 during chronic liver damage in two in vivo models.

The associated ameliorated steatosis development suggests that inhibition of MCP-1 is an interesting novel approach for pharmacological treatment in liver inflammation and steatohepatitis.

Full Text

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Subjects

• Acute Disease
• Animals
• Aptamers, Nucleotide
• Bone Marrow Cells
• Carbon Tetrachloride
• Cells, Cultured
• Chemokine CCL2
• Chemotaxis
• Cytokines
• Disease Progression
• Drug Evaluation, Preclinical
• Drug-Induced Liver Injury
• Drug-Induced Liver Injury, Chronic
• Fatty Liver
• Liver
• Liver Cirrhosis, Experimental
• Macrophages
• Male
• Mice
• Mice, Inbred C57BL

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Authors

• Christer Baeck
• Alexander Wehr
• Karlin Raja Karlmark
• Felix Heymann
• Mihael Vucur
• Nikolaus Gassler
• Sebastian Huss
• Sven Klussmann
• Dirk Eulberg
• Tom Luedde
• Christian Trautwein
• Frank Tacke

Publication date

2012-02-06

Journal

Journal topics

• Gastroenterology

Language

Eng.

Copyright

Department of Medicine III, University Hospital Aachen, Pauwelsstrasse 30, D-52074 Aachen, Germany.

Release reference

Gut. 2012 Mar;61(3):416-26

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