Inhibitor of apoptosis proteins as novel targets in inflammatory processes.

Abstract

Our results reveal IAP antagonism as a profound anti-inflammatory principle in vivo and highlight IAPs as important regulators of inflammatory processes in endothelial cells.

Full Text

• DOI - Arteriosclerosis, thrombosis, and vascular biology (DOI)
• Swets Information Services - full-text online
• Ovid Technologies, Inc. - full-text online
• Lippincott Williams & Wilkins - full-text online
• HighWire Press - full-text online

Subjects

• Animals
• Anti-Inflammatory Agents
• Apoptosis
• Arthritis, Experimental
• Caspases
• Cell Adhesion
• Concanavalin A
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Drug-Induced Liver Injury
• Endothelial Cells
• Enzyme Activation
• Hela Cells
• Humans
• Inhibitor of Apoptosis Proteins
• Intercellular Adhesion Molecule-1
• JNK Mitogen-Activated Protein Kinases
• Leukocytes
• MAP Kinase Kinase Kinases
• Male
• Mice
• Mice, Inbred C57BL
• NF-kappa B
• Proteasome Endopeptidase Complex
• Protein Processing, Post-Translational
• RNA Interference
• Serum Albumin, Bovine
• TNF Receptor-Associated Factor 2
• TNF Receptor-Associated Factor 5
• Time Factors
• Transendothelial and Transepithelial Migration
• Transfection
• Tumor Necrosis Factor-alpha
• Ubiquitination
• p38 Mitogen-Activated Protein Kinases

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Authors

• Bettina A Mayer
• Markus Rehberg
• Annette Erhardt
• Alexander Wolf
• Christoph A Reichel
• Michael Kracht
• Fritz Krombach
• Gisa Tiegs
• Stefan Zahler
• Angelika M Vollmar
• Robert Fürst

Publication date

2011-09-15

Journal

Journal topics

• Arteriosclerosis
• Thrombosis
• Vascular Diseases

Language

Eng.

Copyright

Arteriosclerosis, thrombosis, and vascular biology

Munich Center for System-Based Drug Research, Department of Pharmacy, University of Munich, Germany.

Release reference

Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2240-50

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