For the first time, we have shown that SRW pollen, acting as a functional TLR4 agonist, initiates TLR4-dependent TSLP/OX40L/OX40 signaling, which triggers T(H)2-dominant allergic inflammation.
These findings shed light on the understanding of mucosal epithelial innate immunity and create new therapeutic targets to cure allergic diseases.
2011-12-02
Eng.
The Journal of allergy and clinical immunology
Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA. dequanl [at] bcm.tmc.edu
J Allergy Clin Immunol. 2011 Dec;128(6):1318-1325.e2
© Galenicom 1999-2013