High dose methylprednisolone counteracts the negative effects of rocuronium on diaphragm function.

Abstract

The combination of ROC with a high dose of MP attenuated diaphragm dysfunction caused by ROC probably through inhibition of the calpain and caspase-3 system.

None of these treatments affected the gastrocnemius.

Full Text

• DOI - (DOI)
• Swets Information Services - full-text online
• Springer - full-text online
• Ovid Technologies, Inc. - full-text online
• OhioLINK Electronic Journal Center - full-text online
• EBSCO - full-text online

Subjects

• Androstanols
• Animals
• Diaphragm
• Dose-Response Relationship, Drug
• Glucocorticoids
• Methylprednisolone
• Neuromuscular Nondepolarizing Agents
• Random Allocation
• Rats
• Rats, Wistar
• Respiration, Artificial

Similar articles

• Bench-to-bedside review: Diaphragm muscle function in disuse and acute high-dose corticosteroid treatment. (2009-11-30)
• Diaphragm dysfunction assessed by ultrasonography: influence on weaning from mechanical ventilation. (2011-11-18)
• High-dose colforsin daropate increases diaphragmatic contractility in dogs. (2002-10-10)
• The Effect of Diaphragm Contraction on Upper Airway Collapsibility. (2013-05-02)
• Effects of acute administration of corticosteroids during mechanical ventilation on rat diaphragm. (2008-12-03)
• Different effects of olprinone on contractility in nonfatigued and fatigued diaphragm in dogs. (2000-12-29)
• Susceptibility to cartap-induced lethal effect and diaphragmatic injury via ocular exposure in rabbits. (2003-10-28)
• Neutralization of receptor for advanced glycation end-products and high mobility group box-1 attenuates septic diaphragm dysfunction in rats with peritonitis. (2009-08-19)
• Resistance to D-tubocurarine of the rat diaphragm as compared to a limb muscle: influence of quantal transmitter release and nicotinic acetylcholine receptors. (2009-04-23)

Authors

• Karen Maes
• Dries Testelmans
• Debby Thomas
• Marc Decramer
• Ghislaine Gayan-Ramirez

Publication date

2011-10-18

Journal

Journal topics

• Critical Care
• Intensive Care Units

Language

Eng.

Copyright

Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, 3000, Leuven, Belgium.

Release reference

Intensive Care Med. 2011 Nov;37(11):1865-72

Related books

• Books of Androstanols
• Books of Animals
• Books of Critical Care
• Books of Diaphragm
• Books of Dose-Response Relationship, Drug
• Books of Glucocorticoids
• Books of Intensive Care Units
• Books of Methylprednisolone
• Books of Neuromuscular Nondepolarizing Agents
• Books of Random Allocation
• Books of Rats
• Books of Rats, Wistar
• Books of Respiration, Artificial