Universal hepatitis B vaccination reduces childhood hepatitis B virus-associated membranous nephropathy.

Abstract

Our results revealed a significant decrease in the frequency of HBVMN in children with NS and in long-term follow-up HBsAg carriers.

Children with HBVMN are primarily infected with HBV via horizontal transmission; thus, the significant reduction in horizontal transmission in HBsAg-carrier children in the general population after universal HBV vaccination may explain the reduction of HBVMN in the vaccinated population.

These findings confirm the effectiveness of HBV vaccination on reducing the incidence of HBVMN, possibly through a significant decline in horizontal HBV infection.

Full Text

• DOI - Pediatrics (DOI)
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Subjects

• Child
• Disease Transmission, Infectious
• Female
• Glomerulonephritis, Membranous
• Hepatitis B
• Hepatitis B Vaccines
• Humans
• Male
• Nephrotic Syndrome
• Retrospective Studies

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Authors

• Min-Tser Liao
• Mei-Hwei Chang
• Fu-Gong Lin
• I-Jung Tsai
• Yen-Wen Chang
• Yong-Kwei Tsau

Publication date

2012-02-22

Journal

Language

Eng.

Copyright

Pediatrics

Department of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.

Release reference

Pediatrics. 2011 Sep;128(3):e600-4

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