Effect of Bosentan on systemic sclerosis-associated interstitial lung disease ineligible for cyclophosphamide therapy: a prospective open-label study.

Abstract

The gradual worsening of pulmonary function and HRCT findings in patients treated with bosentan was consistent with the natural course of SSc-associated ILD. This study does not support the use of bosentan for SSc-associated ILD even when CYC treatment is inadvisable.

Full Text

• DOI - The Journal of rheumatology (DOI)
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Subjects

• Adult
• Aged
• Antihypertensive Agents
• Cyclophosphamide
• Female
• Humans
• Lung
• Lung Diseases, Interstitial
• Male
• Middle Aged
• Prospective Studies
• Respiratory Function Tests
• Scleroderma, Systemic
• Sulfonamides
• Treatment Outcome

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Authors

• Yoshiaki Furuya
• Masataka Kuwana

Publication date

2011-10-03

Journal

Journal topics

• Arthritis
• Rheumatic Diseases

Language

Eng.

Copyright

The Journal of rheumatology

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. kuwanam [at] z5.keio.jp

Release reference

J Rheumatol. 2011 Oct;38(10):2186-92

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