Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study.

Abstract

This pilot study represents the most comprehensive study to date examining the role of genetic polymorphisms in osteosarcoma.

Although small and retrospective, it shows that several polymorphisms appear to significantly influence toxicity and clinical outcome.

These deserve prospective validation in the hope of optimizing treatment for resistant disease and reducing the late effects burden.

Full Text

• DOI - Cancer (DOI)
• John Wiley & Sons, Inc. - full-text online
• Swets Information Services - full-text online
• OhioLINK Electronic Journal Center - full-text online
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Subjects

• Adolescent
• Adult
• Antineoplastic Combined Chemotherapy Protocols
• Bone Neoplasms
• Child
• Cisplatin
• Disease-Free Survival
• Doxorubicin
• Female
• Genotype
• Germ Cells
• Humans
• Male
• Middle Aged
• Mitomycin
• Osteosarcoma
• Pilot Projects
• Polymorphism, Genetic
• Treatment Outcome

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Authors

• Rachael E Windsor
• Sandra J Strauss
• Constantinos Kallis
• Nicholas E Wood
• Jeremy S Whelan

Publication date

2012-03-20

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Cancer

London Sarcoma Service, University College Hospital, London, UK. rachael.windsor [at] rmh.nhs.uk

Release reference

Cancer. 2012 Apr;118(7):1856-67

Related books

• Books of Antineoplastic Combined Chemotherapy Protocols
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