Determination of IL28B polymorphisms in liver biopsies obtained after liver transplantation.

Abstract

Our results support that follow-up liver biopsies from LT recipients are not suitable for determining donor IL28B rs12979860 genotype by TaqMan real-time PCR or direct sequencing and that PBMC or reperfusion biopsies should be used instead. Thus, it is very important to obtain adequate samples in order to accurately determine the relative contributions of both donor and recipient.

Full Text

• DOI - Journal of Hepatology (DOI)
• Swets Information Services - full-text online
• OhioLINK Electronic Journal Center - full-text online
• Elsevier Science - full-text online
• EBSCO - full-text online

Subjects

• Base Sequence
• Biopsy
• Cohort Studies
• DNA Primers
• Genetic Techniques
• Hepatitis C, Chronic
• Humans
• Interleukins
• Leukocytes, Mononuclear
• Liver
• Liver Transplantation
• Polymerase Chain Reaction
• Polymorphism, Single Nucleotide
• Tissue Donors

Similar articles

• IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. (2010-11-24)
• The association of IL28B polymorphism and graft survival in patients with hepatitis C undergoing liver transplantation. (2013-01-30)
• Interleukin-28B polymorphisms are associated with histological recurrence and treatment response following liver transplantation in patients with hepatitis C virus infection. (2011-01-21)
• Differential effects of donor and recipient IL28B and DDX58 SNPs on severity of HCV after liver transplantation. (2013-01-15)
• Combinations of simple baseline variables accurately predict sustained virological response in patients with recurrent hepatitis C after liver transplantation. (2012-09-26)
• IL28B polymorphisms are associated with severity of liver disease in human immunodeficiency virus (HIV) patients coinfected with hepatitis C virus. (2012-10-26)
• Increased risk of severe hepatitis C virus recurrence after liver transplantation in patients with a T allele of IL28B rs12979860. (2012-07-14)
• IL28B genotype and the expression of ISGs in normal liver. (2013-03-16)
• IL28B GENOTYPE IS NOT USEFUL FOR PREDICTING TREATMENT OUTCOME IN ASIAN CHRONIC HEPATITIS B PATIENTS TREATED WITH PEGYLATED-INTERFERON-α (2013-01-09)

Authors

• Mairene Coto-Llerena
• Gonzalo Crespo
• Patricia González
• George Koutsoudakis
• Rosa Miquel
• Miquel Navasa
• Xavier Forns
• Sofía Pérez-del-Pulgar

Publication date

2012-01-18

Journal

Journal topics

• Liver
• Liver Diseases

Language

Eng.

Copyright

Journal of Hepatology

Liver Unit, Hospital Clínic, CIBERehd, IDIBAPS, Barcelona, Spain.

Release reference

J Hepatol. 2012 Feb;56(2):355-8

Related books

• Books of Base Sequence
• Books of Biopsy
• Books of Cohort Studies
• Books of DNA Primers
• Books of Genetic Techniques
• Books of Hepatitis C, Chronic
• Books of Interleukins
• Books of Leukocytes, Mononuclear
• Books of Liver
• Books of Liver
• Books of Liver Diseases
• Books of Liver Transplantation
• Books of Polymerase Chain Reaction
• Books of Polymorphism, Single Nucleotide
• Books of Tissue Donors